Micky van de Ven Double Ends The Toffees' Run at New Stadium
Micky van de Ven emerged as the first defender to net twice in a Premier League game for Spurs since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven heads into the net two times in first half
The home side's defender has goal disallowed after video check
Senegalese midfielder scores final goal in dying moments
The defeat is Everton's initial at their new ground
Micky van de Ven scored on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their new ground at the dockside location, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced twice from corners in the first half to put their strong form at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a third to seal the victory.
Jake O'Brien thought he had equalized the scores a short while after Van de Ven's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a handful of chances, while Vicario made a succession of fine saves to guarantee the London club went five away games unbeaten in the Premier League.
But the video assistant referee stepped in, instructing the match official to review the score on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory moves the manager's team into third place in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club stay 14th and are six points clear of the relegation zone.
Tottenham analysis: The defender fulfils role at both ends of the field
After a uninspiring weekday display in the European competition against Monaco, where they mustered a only attempts on goal, Frank chose Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for the substitute after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an offensive threat to be feared.
Spurs' first goal came from a cleverly executed corner routine, with Rodrigo Bentancur directing the ball toward the face of goal for an free Van de Ven to head home.
And Ven de Ven - filling in as captain in the Argentine's absence - notched his second in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, partnering effectively with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by Everton.
Everton analysis: Toffees missing finishing touch
The club's recent stadium had been a fortress, but it appears the novelty may have faded somewhat and fans flocked to the gates after Sarr's third for Tottenham.
The end in the team's winning streak at home will not be a massive worry for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Everton's pair of established centre-forwards - had netted just one league goal combined before the weekend's match.
And they were failed to add to that miserable tally on a damp and dreary night on Merseyside.
The striker's performance was epitomized when he opted to overhead kick a clear chance from near the goal, despite having space and opportunity to readjust for a more conventional shot that would have tested Vicario.
The substitute, too, failed to make an impact after coming on for Beto in the second half.
It wasn't for a lack of opportunity. The majority of the home side's offensive moves came through Grealish and the forward, who relentlessly delivered dangerous balls into the Tottenham box.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.